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Hospital patient's urine turns purple caused by UTI


Purple is probably the least likely color you would ever expect your urine to turn.But for a 70-year-old man, it really happened, the Daily Mail reported.The patient, from India, was 'alarmed' by the bizarre color change in his urine and alerted doctors immediately.Medics were left scratching their heads, before diagnosing the unnamed man with purple urinary bag syndrome.

 

The tale of the rare phenomenon, caused by his UTI, has now been published in a prestigious medical journal.

 

The man was treated at King George's Medical University in Lucknow, around 330 miles (531km) east of New Delhi.

 

He had been fitted with a urinary catheter - a flexible tube that is used to empty the bladder and collect urine in a drainage bag.

The man was diagnosed with purple urinary bag syndrome (PUBS). Photo / BMJ CaseReports

 

The man had been using the catheter in hospital for six months, ahead of planned surgery to cut away part of his enlarged prostate.

 

He called for doctors when he noticed his purple urine. Doctors wrote in the BMJ Case Reports: "He was alarmed by this discoloration."

 

Further analysis by medics, led Dr Siddharth Pandey, revealed his purple urine was actually clear - just not its usual, healthy color.

 

Tests of his urine tested positive for E. coli, leading doctors to believe he had a UTI. Cystitis is usually caused by E. coli bacteria in the bladder.

 

This led Dr Pandey and his colleagues to make the rare diagnosis of purple urinary bag syndrome. He was treated with antibiotics.

 

Doctors say the bluish discoloration of urine is triggered by a series of chemical reactions in the body.

 

Bacteria responsible for the UTI breakdown metabolites of tryptophan - an amino acid found in food.

 

This produces indole, which becomes indoyl sulfate, which then oxidizes into blue-colored indigo and the reddish indirubin.

 

Dr Pandey and his colleagues wrote in the journal: "The combination of indigo and indirubin gives a purple hue to the urine collection bag."

 

However, the discoloration is completely benign, and often the underlying UTI is considered more concerning to medics.

 

Women face a higher risk of developing PUBS because they have a shorter urethra, which leaves them more vulnerable to catching UTIs.

 

Constipation can also boost the odds because it gives bacteria more time to break down tryptophan metabolites in the body.

 

It is unclear how common PUBS is, but it has been described as an 'uncommon phenomenon' in the journal Clinical Infectious Diseases.

 

WHAT IS PURPLE URINARY BAG SYNDROME?

 

Doctors say the bluish discoloration of urine is triggered by a series of chemical reactions in the body.

 

Bacteria responsible for the UTI breakdown metabolites of tryptophan - an amino acid found in food.

 

This produces indole, which becomes indoxyl sulfate, which then oxidizes into blue-colored indigo and the reddish indirubin.

 

Dr Pandey and his colleagues wrote in the journal: 'The combination of indigo and indirubin gives a purple hue to the urine collection bag.'

 

However, the discoloration is completely benign, and often the underlying UTI is considered more concerning to medics.

 

Women face a higher risk of developing PUBS because they have a shorter urethra, which leaves them more vulnerable to catching UTIs.

 

Constipation can also boost the odds because it gives bacteria more time to break down tryptophan metabolites in the body.

 

It is unclear how common PUBS is, but it has been described as an 'uncommon phenomenon' in the journal Clinical Infectious Diseases.

 


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